|Publication Title :
||PREVALENCE OF RIFAMPICIN-RESISTANT TUBERCULOSIS
AND ITS ASSOCIATED FACTORS IN A TERTIARY
HEALTH CARE CENTRE, SOUTH-WEST NIGERIA:
A 5-YEAR REVIEW
||Ojewuyi AR, Odeyemi AO, Odeyemi AO, Olotu AA, Oladipo TS
||Background: Tuberculosis is a chronic disease with associated high morbidity and mortality. In recent decades,
there has been an increase in resistance to drugs used in the treatment of tuberculosis. This is a major stumbling
block in the global fight against tuberculosis. This study was to demonstrate the current prevalence of rifampicinresistant
tuberculosis and its associated predisposing factors in a Teaching Hospital in Nigeria.
Methods: This was a cross-sectional retrospective study involving 359 consecutive patients with bacteriologically
confirmed tuberculosis seen between January 2015 and December 2019. Drug susceptibility testing was performed
for rifampicin using GeneXpert MTB/RIF assay. Relevant information was obtained from the clinical records of
the patients with the use of a well-structured proforma. The data obtained were analysed using the Statistical
Package for Social Sciences (SPSS) version 23.0.
Results: There were a total of 359 patients out of which the majority, 235 (65.5%) were males. The mean age was
39.78+16.31 (range 1 - 90 years). A larger percentage of the subjects were new cases of tuberculosis (n=312,
86.9%), 49(13.6%) were HIV positive. The overall prevalence of rifampicin resistance found was 2.5% (n=9/359).
There was a significant association between gender (p=0.005) and re-treatment (p=0.003). There was no significant
association between rifampicin resistance and other factors including age and HIV.
Conclusion: Male gender and patients on re-treatment for tuberculosis are more at risk of developing resistance
to rifampicin in our environment. There is a need to ensure compliance with all guidelines in the management of
tuberculosis to prevent an increase in drug resistance.